Across TCGA pan-cancer cohorts, SHC4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SHC4 data layer compared with 29 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SHC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SHC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, UCEC, and SARC are the cancer types where SHC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.240	0.790	<.001	28	view →
UCEC	DFS	Median	II,III,IV	0.906	0.308	.039	4	view →
SARC	DFS	Median	All	0.130	0.632	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SHC4 tumor-vs-normal RNA expression · all SHC4 data types