Across TCGA patient cohorts, SHC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,416 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SHC4-associated proteins across cancer lineages are BAG2, LMOD1_S85, and CSPG4. Each is linked with SHC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHC4-to-partner and partner-to-SHC4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC4→partner) and Y-score (partner→SHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BAG2 →	+0.813	+1.391	<.001	<.001	3	4
CCRCC	LMOD1_S85 →	+0.767	+0.259	<.001	<.001	3	4
LSCC	CSPG4 →	+0.732	+0.613	<.001	<.001	3	4
OV	PTPDC1_S394 →	+0.964	+0.339	.009	.003	3	3
COAD	DMD →	+0.436	+0.292	<.001	<.001	3	3
GBM	DNAJA3 →	-0.317	-0.937	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,416 associations by consensus.

Exploration

SHC4 survival (RNA) · tumor vs normal (RNA) · all SHC4 data types