Across TCGA patient cohorts, SHC4 protein abundance is significantly associated with the RNA expression of many other genes, with 211 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHC4-associated genes across cancer lineages are SEC14L2, DHRS7, and LAMA1. Each is linked with SHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC4-to-partner and partner-to-SHC4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC4→partner) and Y-score (partner→SHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEC14L2 →	+0.880	+0.659	.001	.008	3	1
GBM	DHRS7 →	+0.409	+0.566	.001	<.001	3	1
GBM	LAMA1 →	-0.881	-0.535	.009	.001	3	1
GBM	ASB9 →	+0.358	+0.514	.003	.003	3	1
GBM	HOXA2 →	-1.487	-0.777	<.001	<.001	3	1
GBM	HOXA3 →	-1.040	-0.770	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 211 associations by consensus.

Exploration

SHC4 survival (RNA) · tumor vs normal (RNA) · all SHC4 data types