Across TCGA patient cohorts, SHC4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHC4-associated genes across cancer lineages are PCNA, eEF2, and Notch1. Each is linked with SHC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHC4-to-partner and partner-to-SHC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC4→partner) and Y-score (partner→SHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.272	+2.700	<.001	.005	3	3
UCEC	eEF2 →	+0.370	+2.584	.002	.010	3	2
UCEC	Notch1 →	+0.139	+2.235	.003	.005	3	2
UCEC	S6_pS240_S244 →	+0.355	+1.514	.010	.015	3	2
UCEC	TFRC →	+0.379	+1.247	.036	.045	3	2
UCEC	Caspase-8 →	-0.229	-3.143	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

SHC4 survival (RNA) · tumor vs normal (RNA) · all SHC4 data types