Across TCGA cell cohorts, SHC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,638 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SHC4-associated GO terms across cancer lineages are Regulation of autophagy of mitochondrion, Cytosolic transport, and Hippocampus development. Each is linked with SHC4 in more than 8 cancer types. Because this analysis shows association rather than direction, both SHC4-to-partner and partner-to-SHC4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC4→partner) and Y-score (partner→SHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of autophagy of mitochondrion →	+0.087	+1.827	<.001	<.001	3	9
SKIN	Cytosolic transport →	+0.065	+2.153	<.001	<.001	3	8
BLOOD_Leukemia	Hippocampus development →	+0.038	+0.224	<.001	<.001	3	8
BLOOD_Leukemia	Canonical glycolysis →	+0.075	+0.283	.001	.004	3	8
BLOOD_Leukemia	Glucose catabolic process to pyruvate →	+0.075	+0.283	.001	.004	3	8
SKIN	Endosomal transport →	+0.060	+1.964	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,638 associations by consensus.

Exploration

SHC4 survival (RNA) · tumor vs normal (RNA) · all SHC4 data types