Across TCGA cell cohorts, SHC4 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHC4-associated genes across cancer lineages are KRTAP10-3, SH3GL2, and PRKAR2A. Each is linked with SHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC4-to-partner and partner-to-SHC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC4→partner) and Y-score (partner→SHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRTAP10-3 →	+0.032	+5.228	<.001	.005	3	2
LARGE_INTESTINE	SH3GL2 →	+1.054	+3.667	.003	<.001	3	1
LARGE_INTESTINE	PRKAR2A →	+0.613	+3.212	.001	.006	3	1
LARGE_INTESTINE	ACVR1C →	+0.814	+3.082	<.001	.007	3	1
LARGE_INTESTINE	PYURF →	+0.514	+3.067	.002	.009	3	1
LARGE_INTESTINE	BHMT →	+0.343	+3.392	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

SHC4 survival (RNA) · tumor vs normal (RNA) · all SHC4 data types