SHC2

Across TCGA patient cohorts, SHC2 mutation is significantly associated with the RNA expression of many other genes, with 770 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHC2-associated genes across cancer lineages are VDAC2P4, RN7SL598P, and SNORD114-18. Each is linked with SHC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC2-to-partner and partner-to-SHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VDAC2P4 grouped by SHC2-low versus SHC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC2→partner) and Y-score (partner→SHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VDAC2P4 →	+0.057	+2.754	<.001	.009	3	2
SKCM	RN7SL598P →	+0.053	+5.003	<.001	.002	3	2
COAD	SNORD114-18 →	+0.615	+5.409	<.001	.001	3	2
COAD	RPS29P11 →	+0.847	+3.572	<.001	.009	3	2
COAD	RPL22P13 →	+0.715	+3.800	<.001	.005	3	2
COAD	IMMP1LP2 →	+0.266	+3.496	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 770 associations by consensus.

VDAC2P4 by SHC2 expression — SKCM

Explore this box plot interactively →