SHC2

Across TCGA patient cohorts, SHC2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHC2-associated genes across cancer lineages are Cyclin-B1, eIF4E, and Ku80. Each is linked with SHC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC2-to-partner and partner-to-SHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SHC2-low versus SHC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC2→partner) and Y-score (partner→SHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.668	+2.700	.008	.006	3	2
UCEC	eIF4E →	+0.219	+3.013	.021	.018	3	1
UCEC	Ku80 →	+0.310	+3.013	.003	.018	3	1
UCEC	MEK1 →	+0.425	+3.321	.010	.010	3	1
UCEC	MSH2 →	-0.363	-2.295	<.001	.033	3	1
UCEC	Myosin-IIa_pS1943 →	+0.236	+2.013	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Cyclin-B1 by SHC2 expression — UCEC

Explore this box plot interactively →