SHC2

Across TCGA cell cohorts, SHC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,175 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHC2-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of myoblast fusion, and Regulation of TORC1 signaling. Each is linked with SHC2 in more than 12 cancer types. Because this analysis shows association rather than direction, both SHC2-to-partner and partner-to-SHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by SHC2-low versus SHC2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC2→partner) and Y-score (partner→SHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of myoblast fusion →	+0.177	+1.812	<.001	<.001	3	13
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.199	+1.812	<.001	<.001	3	12
OESOPHAGUS	Regulation of TORC1 signaling →	+0.085	+2.078	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of autophagy →	+0.064	+2.116	<.001	<.001	3	11
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.163	+1.773	<.001	<.001	2	12
LUNG_SCLC	Positive regulation of TORC1 signaling →	+0.076	+3.093	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,175 associations by consensus.

Regulation of myoblast fusion by SHC2 expression — OESOPHAGUS

Explore this box plot interactively →