SHC2

Across TCGA cell cohorts, SHC2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SHC2-associated genes across cancer lineages are OR4X2, STRA8, and MAGEB4. Each is linked with SHC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC2-to-partner and partner-to-SHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by SHC2-low versus SHC2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC2→partner) and Y-score (partner→SHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
CNS	STRA8 →	+0.036	+5.754	<.001	.002	3	1
SKIN	MAGEB4 →	+0.010	+5.022	<.001	.002	3	1
SKIN	OR2D3 →	+0.046	+4.095	<.001	.009	3	1
SKIN	PRORY →	+1.013	+4.273	<.001	.006	3	1
SKIN	KIR2DS4 →	+0.009	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR4X2 by SHC2 expression — SOFT_TISSUE

Explore this box plot interactively →