SHC1

Across TCGA pan-cancer cohorts, SHC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SHC1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SHC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where SHC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.554	0.912	<.001	62	view →
LSCC	OS	Quartile	All	0.858	1.000	.002	25	view →
PDAC	OS	Median	IV	0.381	0.951	.006	13	view →
GBM	OS	Tertile	All	0.752	0.898	.007	13	view →
UCEC	DFS	Quartile	All	1.000	0.795	.007	6	view →
LUAD	OS	Median	All	0.893	0.791	.044	3	view →
HNSC	DFS	Quartile	III,IV	1.000	0.878	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SHC1–CCRCC (DFS)

Open the CCRCC breakdown →