SHC1

Across TCGA patient cohorts, SHC1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,037 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHC1-associated genes across cancer lineages are CHKA, CHDH, and CYP4X1. Each is linked with SHC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHC1-to-partner and partner-to-SHC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHC1 versus CHKA in LSCC, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC1→partner) and Y-score (partner→SHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHKA →	-0.650	-0.235	<.001	.001	3	4
CCRCC	CHDH →	-0.996	-0.253	<.001	<.001	3	4
LSCC	CYP4X1 →	-1.485	-0.280	<.001	<.001	3	4
GBM	CASTOR3 →	-0.741	-0.551	<.001	<.001	3	4
CCRCC	IL17RB →	-1.733	-0.269	<.001	<.001	3	4
LSCC	ADAM22 →	-0.692	-0.251	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,037 associations by consensus.

SHC1 vs CHKA — LSCC

Explore this scatter interactively →