SHC1

Across TCGA patient cohorts, SHC1 mutation is significantly associated with the RNA expression of many other genes, with 1,437 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHC1-associated genes across cancer lineages are TMEM41B, MIR4510, and MIR4445. Each is linked with SHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC1-to-partner and partner-to-SHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM41B grouped by SHC1-low versus SHC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC1→partner) and Y-score (partner→SHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM41B →	+0.375	+2.431	.002	.001	3	2
CESC	MIR4510 →	+0.236	+4.757	<.001	.004	3	2
BRCA	MIR4445 →	+0.326	+7.731	<.001	.009	3	2
BLCA	RPL17P13 →	+0.188	+4.284	<.001	<.001	3	2
UCEC	RN7SL237P →	+0.166	+1.496	.002	.008	3	2
UCEC	RN7SKP12 →	+0.123	+2.229	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,437 associations by consensus.

TMEM41B by SHC1 expression — UCEC

Explore this box plot interactively →