SHC1

Across TCGA patient cohorts, SHC1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHC1-associated genes across cancer lineages are eEF2, Acetyl-a-Tubulin-Lys40, and HSP70. Each is linked with SHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC1-to-partner and partner-to-SHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SHC1-low versus SHC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC1→partner) and Y-score (partner→SHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.304	+1.584	.018	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.405	+2.999	.027	.035	3	1
UCEC	HSP70 →	-0.317	-3.169	.028	.018	3	1
UCEC	MEK1 →	+0.313	+2.584	.017	.010	3	1
UCEC	Mre11 →	-0.085	-2.432	.005	.018	3	1
UCEC	MSH2 →	-0.250	-3.143	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eEF2 by SHC1 expression — UCEC

Explore this box plot interactively →