SHC1

Across TCGA cell cohorts, SHC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,740 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SHC1-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Cytosolic transport, and Retrograde transport, endosome to Golgi. Each is linked with SHC1 in more than 11 cancer types. Because this analysis shows association rather than direction, both SHC1-to-partner and partner-to-SHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by SHC1-low versus SHC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC1→partner) and Y-score (partner→SHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Calcium-independent cell-matrix adhesion →	+0.196	+1.432	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.055	+1.032	.003	.003	3	12
LARGE_INTESTINE	Retrograde transport, endosome to Golgi →	+0.056	+0.951	.001	.004	3	12
BREAST	Positive regulation of focal adhesion assembly →	+0.146	+1.106	<.001	.001	3	11
BREAST	Regulation of cell-matrix adhesion →	+0.111	+1.181	<.001	<.001	3	11
BREAST	Regulation of cell-substrate junction organization →	+0.084	+1.042	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,740 associations by consensus.

Calcium-independent cell-matrix adhesion by SHC1 expression — BONE

Explore this box plot interactively →