SHC1

Across TCGA cell cohorts, SHC1 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHC1-associated genes across cancer lineages are IL4, HPCAL4, and TNP1. Each is linked with SHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC1-to-partner and partner-to-SHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL4 grouped by SHC1-low versus SHC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC1→partner) and Y-score (partner→SHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL4 →	+1.224	+3.007	.005	.007	3	1
BLOOD_Leukemia	HPCAL4 →	+0.329	+3.825	<.001	.002	3	1
BLOOD_Leukemia	TNP1 →	+0.095	+4.247	<.001	.004	3	1
BLOOD_Leukemia	ELOVL4 →	+2.753	+3.392	<.001	.007	3	1
BLOOD_Leukemia	VSX2 →	+0.019	+3.744	.008	.003	3	1
BLOOD_Leukemia	CPN1 →	+0.084	+3.607	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

IL4 by SHC1 expression — BLOOD_Leukemia

Explore this box plot interactively →