SHBG

Across TCGA pan-cancer cohorts, SHBG mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SHBG data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SHBG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHBG expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where SHBG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.912	1.000	.018	48	view →
PDAC	DFS	Tertile	III,IV	0.144	0.543	<.001	28	view →
CCRCC	DFS	Quartile	III,IV	0.836	0.458	.011	10	view →
LUAD	DFS	Quartile	III,IV	0.364	1.000	.022	3	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SHBG–COAD (DFS)

Open the COAD breakdown →