SHBG

Across TCGA patient cohorts, SHBG RNA expression is significantly associated with the go_rna of many other GO terms, with 7,105 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible SHBG-associated GO terms across cancer lineages are Monocarboxylic acid catabolic process, Mitochondrial proton-transporting ATP synthase complex assembly, and L-serine metabolic process. Each is linked with SHBG in more than 19 cancer types. Because this analysis shows association rather than direction, both SHBG-to-partner and partner-to-SHBG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocarboxylic acid catabolic process grouped by SHBG-low versus SHBG-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHBG→partner) and Y-score (partner→SHBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	Monocarboxylic acid catabolic process →	+0.057	+2.769	<.001	<.001	3	19
STAD	Mitochondrial proton-transporting ATP synthase complex assembly →	+0.050	+0.293	<.001	<.001	3	19
TGCT	L-serine metabolic process →	+0.062	+0.687	<.001	<.001	3	19
ACC	Proton-transporting two-sector ATPase complex assembly →	+0.048	+0.566	<.001	<.001	2	20
STAD	Tail-anchored membrane protein insertion into ER membrane →	+0.066	+0.313	<.001	<.001	3	18
STAD	Amino acid metabolic process →	+0.048	+0.298	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,105 associations by consensus.

Monocarboxylic acid catabolic process by SHBG expression — CHOL

Explore this box plot interactively →