SHBG

Across TCGA patient cohorts, SHBG mutation is significantly associated with the RNA expression of many other genes, with 859 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHBG-associated genes across cancer lineages are ENTR1, OR4C10P, and RPL17P12. Each is linked with SHBG in more than 1 cancer types. Because this analysis shows association rather than direction, both SHBG-to-partner and partner-to-SHBG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENTR1 grouped by SHBG-low versus SHBG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHBG→partner) and Y-score (partner→SHBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENTR1 →	+0.405	+2.949	.007	<.001	3	2
SARC	OR4C10P →	+0.068	+6.977	<.001	<.001	3	2
SARC	RPL17P12 →	+0.125	+7.398	<.001	<.001	3	2
HNSC	MIR4276 →	+0.413	+7.954	<.001	.008	3	2
UCEC	MFSD14C →	+0.738	+2.617	<.001	.005	3	2
UCEC	PDCD1LG2 →	+0.595	+2.254	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 859 associations by consensus.

ENTR1 by SHBG expression — UCEC

Explore this box plot interactively →