SHBG

Across TCGA patient cohorts, SHBG mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHBG-associated genes across cancer lineages are ERK2, EGFR_pY1068, and ETS-1. Each is linked with SHBG in more than 1 cancer types. Because this analysis shows association rather than direction, both SHBG-to-partner and partner-to-SHBG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SHBG-low versus SHBG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHBG→partner) and Y-score (partner→SHBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.236	+3.700	.008	.001	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.584	.045	.011	3	1
UCEC	ETS-1 →	+0.293	+3.169	.048	.019	3	1
UCEC	JNK2 →	+0.258	+2.584	.005	.011	3	1
UCEC	Ku80 →	+0.296	+2.598	.007	.006	3	1
UCEC	Shc_pY317 →	-0.154	-3.000	.029	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by SHBG expression — UCEC

Explore this box plot interactively →