SHBG

Across TCGA cell cohorts, SHBG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,448 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible SHBG-associated GO terms across cancer lineages are Positive regulation of TOR signaling, Positive regulation of TORC1 signaling, and Regulation of TOR signaling. Each is linked with SHBG in more than 9 cancer types. Because this analysis shows association rather than direction, both SHBG-to-partner and partner-to-SHBG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of TOR signaling grouped by SHBG-low versus SHBG-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHBG→partner) and Y-score (partner→SHBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of TOR signaling →	+0.100	+0.689	<.001	.001	3	10
STOMACH	Positive regulation of TORC1 signaling →	+0.092	+0.558	<.001	<.001	3	8
STOMACH	Regulation of TOR signaling →	+0.064	+0.554	<.001	<.001	3	8
STOMACH	Regulation of macroautophagy →	+0.086	+0.628	<.001	<.001	3	7
SOFT_TISSUE	Autophagosome organization →	+0.054	+0.493	<.001	<.001	3	7
OVARY	Proteasomal ubiquitin-independent protein catabolic process →	+0.070	+0.326	.007	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,448 associations by consensus.

Positive regulation of TOR signaling by SHBG expression — STOMACH

Explore this box plot interactively →