SHANK3

Across TCGA pan-cancer cohorts, SHANK3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SHANK3 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SHANK3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SHANK3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where SHANK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.911	0.279	.001	64	view →
LUAD	DFS	Tertile	III,IV	0.399	0.928	.004	15	view →
LSCC	DFS	Quartile	II,III,IV	0.750	1.000	.004	7	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	6	view →
UCEC	OS	Tertile	III,IV	0.265	1.000	.049	4	view →
HNSC	OS	Tertile	All	0.924	0.993	.034	2	view →
GBM	DFS	Tertile	All	0.800	0.698	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SHANK3–CCRCC (DFS)

Open the CCRCC breakdown →