SHANK3

Across TCGA patient cohorts, SHANK3 protein abundance is significantly associated with the RNA expression of many other genes, with 16,155 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SHANK3-associated genes across cancer lineages are DIPK2B, ADGRL4, and EMCN. Each is linked with SHANK3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SHANK3-to-partner and partner-to-SHANK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHANK3 versus DIPK2B in CCRCC, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK3→partner) and Y-score (partner→SHANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DIPK2B →	+1.176	+0.575	<.001	<.001	3	8
CCRCC	ADGRL4 →	+1.040	+0.501	<.001	<.001	3	8
CCRCC	EMCN →	+1.803	+0.602	<.001	<.001	3	8
CCRCC	S1PR1 →	+1.190	+0.532	<.001	<.001	3	8
CCRCC	ZNF366 →	+0.846	+0.517	<.001	<.001	3	8
CCRCC	RASIP1 →	+1.168	+0.613	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,155 associations by consensus.

SHANK3 vs DIPK2B — CCRCC

Explore this scatter interactively →