SHANK3

Across TCGA patient cohorts, SHANK3 mutation is significantly associated with the RNA expression of many other genes, with 1,544 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHANK3-associated genes across cancer lineages are LACTB, KCTD9, and SEC24A. Each is linked with SHANK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHANK3-to-partner and partner-to-SHANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LACTB grouped by SHANK3-low versus SHANK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK3→partner) and Y-score (partner→SHANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LACTB →	+0.545	+3.615	<.001	.001	3	3
UCEC	KCTD9 →	+0.438	+1.470	.006	.008	3	3
UCEC	SEC24A →	+0.492	+2.518	.002	.001	3	3
UCEC	RBP1 →	-1.146	-2.406	.001	.003	3	3
COAD	EDEM1 →	+0.501	+2.598	.002	.006	3	3
UCEC	ECPAS →	+0.294	+2.032	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,544 associations by consensus.

LACTB by SHANK3 expression — COAD

Explore this box plot interactively →