SHANK3

Across TCGA cell cohorts, SHANK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,616 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SHANK3-associated GO terms across cancer lineages are Regulation of cytoplasmic pattern recognition receptor signaling pathway, Regulation of protein localization to centrosome, and Heterochromatin formation. Each is linked with SHANK3 in more than 12 cancer types. Because this analysis shows association rather than direction, both SHANK3-to-partner and partner-to-SHANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytoplasmic pattern recognition receptor signaling pathway grouped by SHANK3-low versus SHANK3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK3→partner) and Y-score (partner→SHANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.056	+0.999	.003	.004	3	13
LUNG_SCLC	Regulation of protein localization to centrosome →	+0.141	+1.139	<.001	<.001	3	12
BONE	Heterochromatin formation →	+0.083	+1.412	.006	<.001	3	12
BONE	DNA-templated transcription initiation →	+0.075	+1.263	.003	<.001	3	12
KIDNEY	Negative regulation of transcription by RNA polymerase III →	+0.146	+1.180	<.001	<.001	3	11
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.162	+1.245	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,616 associations by consensus.

Regulation of cytoplasmic pattern recognition receptor signaling pathway by SHANK3 expression — OESOPHAGUS

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