SHANK3

Across TCGA cell cohorts, SHANK3 mutation is significantly associated with the RNA expression of many other genes, with 1,324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHANK3-associated genes across cancer lineages are TMEM52, NIPSNAP1, and RPS5. Each is linked with SHANK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHANK3-to-partner and partner-to-SHANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM52 grouped by SHANK3-low versus SHANK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK3→partner) and Y-score (partner→SHANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM52 →	+1.373	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	NIPSNAP1 →	+0.800	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	RPS5 →	+0.523	+2.546	<.001	.001	3	2
LARGE_INTESTINE	MMACHC →	+0.741	+2.222	<.001	.001	3	2
LARGE_INTESTINE	TGS1 →	+0.510	+3.409	.001	<.001	3	2
LARGE_INTESTINE	FEM1A →	+0.565	+2.458	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,324 associations by consensus.

TMEM52 by SHANK3 expression — LARGE_INTESTINE

Explore this box plot interactively →