SHANK2

Across TCGA patient cohorts, SHANK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,593 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHANK2-associated proteins across cancer lineages are SHANK2_S96, SHANK2_S452, and SHANK2_S43. Each is linked with SHANK2 in more than 9 cancer types. Because this analysis shows association rather than direction, both SHANK2-to-partner and partner-to-SHANK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHANK2 versus SHANK2_S96 in OV, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK2→partner) and Y-score (partner→SHANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SHANK2_S96 →	+1.715	+1.294	<.001	<.001	3	10
HNSC	SHANK2_S452 →	+1.013	+1.525	<.001	<.001	3	7
BRCA	SHANK2_S43 →	+0.799	+1.026	<.001	<.001	3	6
HNSC	SHANK2_S67 →	+1.384	+1.437	<.001	<.001	3	6
HNSC	SHANK2_S1071 →	+0.988	+1.283	<.001	<.001	3	6
LSCC	SHANK2_S1234 →	+1.019	+0.971	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,593 associations by consensus.

SHANK2 vs SHANK2_S96 — OV

Explore this scatter interactively →