SHANK2

Across TCGA patient cohorts, SHANK2 mutation is significantly associated with the RNA expression of many other genes, with 7,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHANK2-associated genes across cancer lineages are CHCHD1, DLGAP5, and UQCRH. Each is linked with SHANK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SHANK2-to-partner and partner-to-SHANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD1 grouped by SHANK2-low versus SHANK2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK2→partner) and Y-score (partner→SHANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CHCHD1 →	+0.605	+3.651	<.001	.001	3	6
UCEC	DLGAP5 →	+0.566	+1.368	<.001	<.001	3	6
UCEC	UQCRH →	+0.607	+1.379	.001	<.001	3	5
COAD	MNAT1 →	+0.387	+2.235	.003	.005	3	5
STAD	CDKN3 →	+0.696	+3.584	.009	.002	2	6
SKCM	NEK2 →	+0.469	+1.434	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,714 associations by consensus.

CHCHD1 by SHANK2 expression — STAD

Explore this box plot interactively →