SHANK2

Across TCGA cell cohorts, SHANK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,876 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SHANK2-associated GO terms across cancer lineages are Negative regulation of transforming growth factor beta production, Negative regulation of supramolecular fiber organization, and Cell-cell adhesion mediated by cadherin. Each is linked with SHANK2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SHANK2-to-partner and partner-to-SHANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transforming growth factor beta production grouped by SHANK2-low versus SHANK2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK2→partner) and Y-score (partner→SHANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of transforming growth factor beta production →	+0.234	+1.445	.002	.001	3	9
OESOPHAGUS	Negative regulation of supramolecular fiber organization →	+0.080	+1.319	.001	.004	3	9
URINARY_TRACT	Cell-cell adhesion mediated by cadherin →	+0.156	+1.182	<.001	.006	3	9
LUNG_NSCLC_LUAD	Cell-substrate junction assembly →	+0.130	+1.048	<.001	.001	3	9
OVARY	ERBB2 signaling pathway →	+0.138	+1.232	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.078	+1.518	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,876 associations by consensus.

Negative regulation of transforming growth factor beta production by SHANK2 expression — PANCREAS

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