SHANK2

Across TCGA cell cohorts, SHANK2 mutation is significantly associated with the RNA expression of many other genes, with 887 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHANK2-associated genes across cancer lineages are OR1L4, OR6V1, and PHF5A. Each is linked with SHANK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHANK2-to-partner and partner-to-SHANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L4 grouped by SHANK2-low versus SHANK2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK2→partner) and Y-score (partner→SHANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR1L4 →	+0.053	+4.369	<.001	.008	3	2
SOFT_TISSUE	OR6V1 →	+0.067	+5.954	<.001	<.001	3	2
LARGE_INTESTINE	PHF5A →	+0.537	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	ZMYND8 →	-0.629	-2.115	.003	.004	3	2
LARGE_INTESTINE	CA2 →	+1.424	+1.949	.002	.002	3	2
LARGE_INTESTINE	KDSR →	+0.787	+2.458	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 887 associations by consensus.

OR1L4 by SHANK2 expression — SOFT_TISSUE

Explore this box plot interactively →