SHANK2-AS3

Across TCGA pan-cancer cohorts, SHANK2-AS3 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated SHANK2-AS3 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher SHANK2-AS3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SHANK2-AS3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and STAD show a favorable association.

MESO, SKCM, and UCS are the cancer types where SHANK2-AS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.036	0.563	<.001	63	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	45	view →
UCS	OS	Tertile	III,IV	0.204	0.518	.013	36	view →
UCEC	DFS	Tertile	III,IV	0.375	0.636	.006	34	view →
LUSC	OS	Tertile	III,IV	0.516	0.723	.021	27	view →
CHOL	OS	Tertile	III,IV	0.290	0.855	.027	24	view →
BRCA	OS	Median	III,IV	0.886	0.785	.018	21	view →
LIHC	DFS	Tertile	All	0.423	0.572	.021	15	view →
STAD	OS	Quartile	IV	0.497	0.149	.034	8	view →
KICH	DFS	Tertile	III,IV	1.000	0.486	.033	3	view →
THYM	DFS	Tertile	All	0.504	0.809	.030	3	view →
ESCA	DFS	Tertile	III,IV	0.474	0.277	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SHANK2-AS3–MESO (OS)

Open the MESO breakdown →