SHANK2-AS2

Across TCGA pan-cancer cohorts, SHANK2-AS2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SHANK2-AS2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SHANK2-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHANK2-AS2 expression acts as an unfavorable survival marker, although some lineages such as OV and LGG show a favorable association.

HNSC, LUSC, and THCA are the cancer types where SHANK2-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.532	0.694	<.001	132	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	71	view →
THCA	OS	Tertile	II,III,IV	0.483	0.856	<.001	54	view →
ACC	OS	Tertile	All	0.160	0.626	.013	51	view →
KIRC	DFS	Tertile	All	0.701	0.840	.004	42	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
SKCM	OS	Tertile	IV	0.247	0.752	.004	27	view →
KIRP	OS	Tertile	II,III,IV	0.189	0.654	.005	24	view →
OV	DFS	Median	III,IV	0.416	0.325	.004	24	view →
LGG	OS	Tertile	All	0.942	0.866	.001	23	view →
COAD	DFS	Tertile	II,III,IV	0.694	0.778	.020	22	view →
READ	DFS	Tertile	IV	0.321	0.670	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SHANK2-AS2–HNSC (DFS)

Open the HNSC breakdown →