SHANK1

Across TCGA pan-cancer cohorts, SHANK1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SHANK1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SHANK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHANK1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC and GBM are the cancer types where SHANK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.680	0.969	.001	29	view →
GBM	DFS	Quartile	All	0.787	0.611	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SHANK1–CCRCC (DFS)

Open the CCRCC breakdown →