SHANK1

Across TCGA patient cohorts, SHANK1 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SHANK1-associated genes across cancer lineages are Caveolin-1, 4E-BP1_pT70, and RAD51. Each is linked with SHANK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHANK1-to-partner and partner-to-SHANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by SHANK1-low versus SHANK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK1→partner) and Y-score (partner→SHANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caveolin-1 →	-0.588	-2.115	.008	.017	3	4
COAD	4E-BP1_pT70 →	+0.084	+1.745	.025	.004	3	4
LUAD	RAD51 →	+0.189	+2.338	.006	.017	3	3
LUSC	FoxM1 →	+0.227	+3.477	.020	.002	3	3
BLCA	TFRC →	+0.492	+3.012	.022	.018	2	4
COAD	A-Raf_pS299 →	-0.166	-2.304	.001	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

Caveolin-1 by SHANK1 expression — COAD

Explore this box plot interactively →