SHANK1

Across TCGA cell cohorts, SHANK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,490 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHANK1-associated GO terms across cancer lineages are Protein monoubiquitination, Regulation of epinephrine secretion, and Neuron-glial cell signaling. Each is linked with SHANK1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SHANK1-to-partner and partner-to-SHANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein monoubiquitination grouped by SHANK1-low versus SHANK1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK1→partner) and Y-score (partner→SHANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protein monoubiquitination →	+0.048	+1.693	<.001	<.001	3	9
OVARY	Regulation of epinephrine secretion →	+1.024	+1.149	<.001	.001	3	8
LUNG_SCLC	Neuron-glial cell signaling →	+1.163	+1.894	<.001	<.001	3	8
LUNG_SCLC	Negative regulation of epinephrine secretion →	+1.199	+2.260	<.001	<.001	3	8
BONE	Lipoprotein localization →	+0.170	+3.733	<.001	<.001	3	8
BONE	Aldosterone biosynthetic process →	+1.261	+2.733	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,490 associations by consensus.

Protein monoubiquitination by SHANK1 expression — BLOOD_Leukemia

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