SHANK1

Across TCGA cell cohorts, SHANK1 mutation is significantly associated with the RNA expression of many other genes, with 848 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHANK1-associated genes across cancer lineages are SMCP, SLURP1, and MRGPRG. Each is linked with SHANK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHANK1-to-partner and partner-to-SHANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMCP grouped by SHANK1-low versus SHANK1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHANK1→partner) and Y-score (partner→SHANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SMCP →	+0.136	+5.369	<.001	.004	3	2
CNS	SLURP1 →	+0.179	+3.467	<.001	<.001	3	2
LUNG_NSCLC_LUAD	MRGPRG →	+0.013	+2.281	<.001	.004	3	2
BLOOD_Leukemia	CCDC190 →	+0.036	+3.926	<.001	.003	3	2
BLOOD_Leukemia	SUPT20HL1 →	+0.178	+3.234	<.001	.008	3	2
BLOOD_Leukemia	USP17L7 →	+0.109	+3.714	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 848 associations by consensus.

SMCP by SHANK1 expression — SOFT_TISSUE

Explore this box plot interactively →