SH3YL1

Across TCGA pan-cancer cohorts, SH3YL1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SH3YL1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SH3YL1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SH3YL1 expression acts as an unfavorable survival marker.

COAD, LUSC, and UCEC are the cancer types where SH3YL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.265	0.667	<.001	44	view →
LUSC	OS	Median	II,III,IV	0.112	0.743	<.001	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SH3YL1–COAD (DFS)

Open the COAD breakdown →