SH3YL1

Across TCGA pan-cancer cohorts, SH3YL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SH3YL1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SH3YL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SH3YL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where SH3YL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.884	.012	23	view →
UCEC	DFS	Median	All	0.959	0.738	<.001	22	view →
HNSC	OS	Median	II,III,IV	0.793	0.597	.010	13	view →
LUAD	DFS	Median	III,IV	0.554	0.879	.028	4	view →
PDAC	OS	Quartile	All	0.887	0.750	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SH3YL1–CCRCC (OS)

Open the CCRCC breakdown →