SH3YL1

Across TCGA patient cohorts, SH3YL1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,000 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH3YL1-associated genes across cancer lineages are KIRREL1, LINC01506, and PIGR. Each is linked with SH3YL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3YL1-to-partner and partner-to-SH3YL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3YL1 versus KIRREL1 in CCRCC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3YL1→partner) and Y-score (partner→SH3YL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIRREL1 →	-0.532	-0.318	.001	.001	3	3
CCRCC	LINC01506 →	+0.917	+0.382	<.001	<.001	3	3
UCEC	PIGR →	+2.988	+0.521	.002	.004	3	3
UCEC	PDXP-DT →	-0.373	-0.434	.001	.001	3	3
CCRCC	LIPI →	-0.175	-0.310	.007	.003	3	2
CCRCC	RPS3AP19 →	-0.561	-0.425	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,000 associations by consensus.

SH3YL1 vs KIRREL1 — CCRCC

Explore this scatter interactively →