SH3YL1

Across TCGA patient cohorts, SH3YL1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3YL1-associated genes across cancer lineages are MEK1, VHL, and ATM. Each is linked with SH3YL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3YL1-to-partner and partner-to-SH3YL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SH3YL1-low versus SH3YL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3YL1→partner) and Y-score (partner→SH3YL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.377	+2.584	.008	.010	3	2
UCEC	VHL →	-1.106	-2.906	<.001	.001	3	2
UCEC	ATM →	-0.687	-2.502	<.001	.002	3	2
UCEC	BRD4 →	+0.278	+3.459	.008	.004	3	2
UCEC	eEF2 →	+0.357	+2.459	.011	.019	3	1
UCEC	EGFR_pY1068 →	-0.310	-2.502	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MEK1 by SH3YL1 expression — UCEC

Explore this box plot interactively →