SH3TC2

Across TCGA patient cohorts, SH3TC2 mutation is significantly associated with the RNA expression of many other genes, with 4,390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3TC2-associated genes across cancer lineages are ZDHHC3, SARS1, and RAD51. Each is linked with SH3TC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SH3TC2-to-partner and partner-to-SH3TC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZDHHC3 grouped by SH3TC2-low versus SH3TC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC2→partner) and Y-score (partner→SH3TC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZDHHC3 →	+0.222	+1.579	.006	.004	3	4
UCEC	SARS1 →	+0.368	+1.238	<.001	.006	3	4
UCEC	RAD51 →	+0.821	+1.928	<.001	<.001	3	4
UCEC	SAR1A →	+0.297	+1.625	.002	.002	3	4
UCEC	YARS1 →	+0.527	+1.594	<.001	<.001	3	4
UCEC	CCT4 →	+0.387	+1.217	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,390 associations by consensus.

ZDHHC3 by SH3TC2 expression — UCEC

Explore this box plot interactively →