SH3TC2

Across TCGA cell cohorts, SH3TC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,326 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3TC2-associated GO terms across cancer lineages are Regulation of Rho protein signal transduction, Regulation of actin polymerization or depolymerization, and Small GTPase-mediated signal transduction. Each is linked with SH3TC2 in more than 11 cancer types. Because this analysis shows association rather than direction, both SH3TC2-to-partner and partner-to-SH3TC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Rho protein signal transduction grouped by SH3TC2-low versus SH3TC2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC2→partner) and Y-score (partner→SH3TC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of Rho protein signal transduction →	+0.118	+1.941	<.001	<.001	3	12
LARGE_INTESTINE	Regulation of actin polymerization or depolymerization →	+0.089	+1.674	<.001	<.001	3	12
OESOPHAGUS	Small GTPase-mediated signal transduction →	+0.064	+1.724	.001	<.001	3	12
BONE	Regulation of cell-matrix adhesion →	+0.146	+1.091	<.001	<.001	3	12
LARGE_INTESTINE	Regulation of actin filament length →	+0.088	+1.740	<.001	<.001	3	12
BONE	Cell-substrate adhesion →	+0.150	+1.277	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,326 associations by consensus.

Regulation of Rho protein signal transduction by SH3TC2 expression — LARGE_INTESTINE

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