SH3TC2

Across TCGA cell cohorts, SH3TC2 mutation is significantly associated with the RNA expression of many other genes, with 793 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3TC2-associated genes across cancer lineages are CSH1, OR2B3, and APOC4. Each is linked with SH3TC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3TC2-to-partner and partner-to-SH3TC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSH1 grouped by SH3TC2-low versus SH3TC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC2→partner) and Y-score (partner→SH3TC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CSH1 →	+0.059	+4.339	<.001	.002	3	2
LUNG_NSCLC_LUAD	OR2B3 →	+0.016	+4.228	<.001	<.001	3	2
SOFT_TISSUE	APOC4 →	+0.107	+4.459	<.001	.001	3	1
URINARY_TRACT	IDI2 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	SCGB1D1 →	+0.073	+5.087	<.001	.004	3	1
URINARY_TRACT	MYH4 →	+0.116	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 793 associations by consensus.

CSH1 by SH3TC2 expression — BLOOD_Leukemia

Explore this box plot interactively →