SH3TC2

Across TCGA cell cohorts, SH3TC2 mutation is significantly associated with the mutation status of many other genes, with 5,286 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3TC2-associated genes across cancer lineages are CHD7, GLI3, and GPLD1. Each is linked with SH3TC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SH3TC2-to-partner and partner-to-SH3TC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHD7 grouped by SH3TC2-low versus SH3TC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC2→partner) and Y-score (partner→SH3TC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHD7 →	+1.788	+2.280	<.001	<.001	1	5
SKIN	GLI3 →	+3.245	+4.807	<.001	<.001	1	5
OVARY	GPLD1 →	+3.217	+3.684	.006	.006	1	5
LARGE_INTESTINE	CELSR1 →	+1.578	+2.370	.001	.001	1	5
LUNG_NSCLC_LUAD	SNAP91 →	+4.303	+4.000	.001	.001	1	4
BLOOD_Leukemia	TPCN2 →	+3.313	+3.430	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,286 associations by consensus.

CHD7 by SH3TC2 expression — LARGE_INTESTINE

Explore this box plot interactively →