SH3RF3

Across TCGA pan-cancer cohorts, SH3RF3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SH3RF3 data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SH3RF3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SH3RF3 expression acts as an unfavorable survival marker, although some lineages such as LIHC show a favorable association.

LUSC, LUAD, and LIHC are the cancer types where SH3RF3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	24	view →
LUAD	OS	Median	II,III,IV	0.079	0.677	<.001	6	view →
LIHC	DFS	Median	III,IV	1.000	0.223	.039	4	view →
SKCM	OS	Median	All	0.581	0.791	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SH3RF3–LUSC (DFS)

Open the LUSC breakdown →