SH3RF3

Across TCGA patient cohorts, SH3RF3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3RF3-associated genes across cancer lineages are Caspase-7-cleavedD198, Lck, and Rad50. Each is linked with SH3RF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3RF3-to-partner and partner-to-SH3RF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SH3RF3-low versus SH3RF3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF3→partner) and Y-score (partner→SH3RF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.365	+2.467	<.001	.011	3	3
COAD	Lck →	+0.316	+2.321	.017	.033	3	2
COAD	Rad50 →	-0.335	-3.000	.001	.034	3	2
COAD	Stathmin →	+0.190	+3.182	.004	.009	3	2
COAD	4E-BP1_pT70 →	+0.169	+3.321	.001	.009	3	2
UCEC	mTOR_pS2448 →	-0.108	-1.886	.032	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Caspase-7-cleavedD198 by SH3RF3 expression — COAD

Explore this box plot interactively →