SH3RF3

Across TCGA cell cohorts, SH3RF3 mutation is significantly associated with the RNA expression of many other genes, with 128 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3RF3-associated genes across cancer lineages are TRHR, SULT1C3, and SLC5A8. Each is linked with SH3RF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3RF3-to-partner and partner-to-SH3RF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRHR grouped by SH3RF3-low versus SH3RF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF3→partner) and Y-score (partner→SH3RF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRHR →	+0.033	+2.447	.005	.003	3	2
PANCREAS	SULT1C3 →	+0.171	+4.491	.001	.003	3	1
PANCREAS	SLC5A8 →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	CBLN4 →	+0.005	+4.614	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.011	+4.266	<.001	.004	3	1
CNS	BHLHE23 →	+0.017	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 128 associations by consensus.

TRHR by SH3RF3 expression — LARGE_INTESTINE

Explore this box plot interactively →