SH3RF3-AS1

Across TCGA pan-cancer cohorts, SH3RF3-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SH3RF3-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SH3RF3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SH3RF3-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

UVM, KIRC, and CESC are the cancer types where SH3RF3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.316	0.693	.003	77	view →
KIRC	OS	Median	All	0.723	0.549	<.001	46	view →
CESC	DFS	Median	All	0.657	0.824	<.001	34	view →
KIRP	DFS	Quartile	II,III,IV	0.900	0.544	.001	32	view →
BLCA	OS	Median	II,III,IV	0.551	0.674	.008	23	view →
LUSC	OS	Tertile	III,IV	0.301	0.546	.012	22	view →
HNSC	DFS	Quartile	IV	0.619	0.275	.001	18	view →
THCA	DFS	Median	All	0.922	0.868	.018	15	view →
UCS	DFS	Quartile	III,IV	0.456	0.096	.028	14	view →
READ	DFS	Quartile	III,IV	0.575	0.271	.014	8	view →
THYM	DFS	Tertile	II,III,IV	0.966	0.834	.013	7	view →
ACC	OS	Tertile	IV	0.886	0.327	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SH3RF3-AS1–UVM (DFS)

Open the UVM breakdown →