SH3RF2

Across TCGA patient cohorts, SH3RF2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3RF2-associated genes across cancer lineages are Caspase-7-cleavedD198, Acetyl-a-Tubulin-Lys40, and JNK2. Each is linked with SH3RF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3RF2-to-partner and partner-to-SH3RF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SH3RF2-low versus SH3RF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF2→partner) and Y-score (partner→SH3RF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.598	+2.135	.007	.010	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.464	+1.415	.014	.046	3	2
UCEC	JNK2 →	+0.250	+2.169	<.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.127	-2.446	.023	.018	3	2
UCEC	VHL →	-0.850	-2.222	<.001	.010	3	2
UCEC	4E-BP1 →	+0.476	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by SH3RF2 expression — UCEC

Explore this box plot interactively →