SH3RF2

Across TCGA cell cohorts, SH3RF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,462 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SH3RF2-associated GO terms across cancer lineages are Fibroblast migration, Actin filament organization, and Cellular response to external stimulus. Each is linked with SH3RF2 in more than 12 cancer types. Because this analysis shows association rather than direction, both SH3RF2-to-partner and partner-to-SH3RF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibroblast migration grouped by SH3RF2-low versus SH3RF2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF2→partner) and Y-score (partner→SH3RF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Fibroblast migration →	+0.212	+2.293	.001	.003	3	13
OVARY	Actin filament organization →	+0.063	+1.470	.001	.002	3	12
LUNG_NSCLC_LUAD	Cellular response to external stimulus →	+0.090	+1.657	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Intestinal absorption →	+0.178	+2.516	<.001	<.001	3	11
OVARY	Positive regulation of response to cytokine stimulus →	+0.110	+1.596	<.001	<.001	3	11
BREAST	Regulation of cytokine-mediated signaling pathway →	+0.078	+2.232	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,462 associations by consensus.

Fibroblast migration by SH3RF2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →